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Resverlogix Announces the commencement of an Orphan Disease Program specific for Complement Mediated Diseases

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On September 24, Resverlogix Corp. announced the commencement of an Orphan Disease Program specific for Complement Mediated Diseases. Data generated by Resverlogix has demonstrated that BET inhibition by apabetalone (RVX-208) has effects on multiple biological pathways that underlie disease pathology. Also, it has been shown to modulate the complement and coagulation pathways, known to play roles in cardiovascular disease and a variety of orphan indications. Resverlogix plans to pursue a pilot proof-of-concept trial in complement mediated diseases, with the first clinical trial in Paroxysmal Nocturnal Hemoglobinuria (PNH).

 

Apabetalone (RVX-208) has been shown to downregulate multiple components of the complement and coagulation pathways both in vitro, in vivo and in the plasma of select patients treated with RVX-208 (from the ASSURE clinical trial).

 

“We believe that the next step in testing the potential for apabetalone to downregulate the levels (and possibly the activity) of complement components in humans, is to test it in patients with an overactive complement cascade,” stated Dr. Ewelina Kulikowski, vice president of scientific development at Resverlogix. “Based on this data, an initial Phase 2 pilot trial to test the effect of apabetalone treatment in a small group of PNH patients is proposed,” she added.

Whole Foods to cut 1,500 jobs

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Whole Foods to cut 1

Whole Foods announced Monday that it plans to cut 1,500 jobs—or about 1.6 per cent of its workforce—over the next two months. The grocery chain announced Monday that this decision is a direct result of its strategy to lower prices for customers.

“We believe this is an important step to evolve Whole Foods Market in a rapidly changing marketplace,” says co-CEO Walter Robb, who also notes that the job cuts will allow the company to focus more on upgrading its technology.

These cuts follow Whole Foods’ addition of more than 9,000 jobs in the past year. Currently, it has about 91,000 employees and 431 stores across the U.S., U.K., and Canada.

The company expects “a significant percentage” of employees being let go to find other jobs among Whole Foods’ open positions, including those available at more than 100 of its new stores.

New pharmacy and health food store in Waterford, ON

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New pharmacy and health food store in Waterford

Waterford, a small town in Ontario, has announced the opening of Waterford Pharmacy and Health Food. The store, opened by co-owners Kay Eshkour and Amin Boomani, will contain both a full service pharmacy and natural health food products.

“An awareness of healthy living, including proper diet and exercise, is the focus of this pharmacy,” says Eshkour, who explains that as a pharmacist, he’s aware of the nutrient deficiencies that the use of pharmaceutical drugs may cause. With the holistic approach at this store, he says, he will be able to recommend suitable supplements to offset these effects.

The store will also feature educational services, including group and individual seminars about various health issues, vitamins and supplements and other natural remedies. Cassandra Griffiths, a certified nutrition and weight loss adviser, will administer these sessions.

Store hours are Monday to Friday from 9:30 a.m. to 6 p.m. and Saturday from 10 a.m. to 4 p.m. On Sundays, the pharmacy is closed, but the health food section is open from 10 a.m. to 4 p.m. For more information, contact the store directly at 519-443-0123.

Topping the Sales Charts

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Topping the Sales Charts

Daniel Lupu has taken the art of supplement and health retail to another level. Here’s how education, passion and a desire to help have grown his Toronto-based Nutrition House.

By Mehreen Shahid

When Daniel Lupu was a teenager, his parents would give him five dollars to go to the arcade at the local Winnipeg mall. Instead, he’d visit Nutrition House and comb the isles, jotting down notes on product ingredients. Then he would go to the library and spend hours reading up on the ingredients in further details.

This early introduction to the healing powers of supplements and Lupu’s staunch belief in the curing properties of food, pushed him to study homeopathy.

After achieving a Bachelor of Science from the University of Manitoba, Lupu enrolled at the Manitoba College of Homeopathic Medicine to become a homeopath.

After moving to Toronto, he established two private homeopathic medicine practices, one at Yonge and Eglinton from 2004–2009, followed by one at Christie and Bloor from 2009–2013. After almost a decade of treating people with homeopathic medicine, Lupu decided to get involved in the retail side of the business.

“I could reach more people as a homeopath if I were in the business of health products,” he says. His opportunity came at a Toronto trade show in 2013, and he put in an offer for his own Nutrition House location at Hudson Bay Centre on Bloor Street, Toronto. After a month of negotiations, the store was finally his.

Give the People What They Want

“For any retail business to succeed you need to have visibility, customer interaction, acquisition and location,” says Lupu. He had the location part covered, with a 600-square foot store at Yonge and Bloor Street.

To increase his store’s visibility and customer interaction, he decided to take advantage of being close to three of the city’s most popular GoodLife gyms. “Right away, I started networking with GoodLife and tapping into the category of 18 to 35 year olds,” says the 40-year-old entrepreneur. “I looked at other nutrition stores in the area, and they were selling a lot of sports nutrition; as a business you have to have something for everybody.” He wanted to rebrand his store as a place where patrons can get healthy snacks as well as sports supplements.

Lupu recast the store as a Sports Nutrition House, and took the store from an inventory of $27k, which was less than the bare minimum Nutrition House inventory requirement of $60k, to four times that within one quarter.

“My current inventory is at $170k, with the long term goal of keeping it closer to $150k year round,” he says.

As a sub-lease tenant from Nutrition House Canada, the HBC store follows the same inventory list as does every other national franchisee. “We have a core group of products that every store is mandated to carry for consistency across the nation. However, as a storeowner, I have the ability to carry brands that my customers are looking for.”

When he first started out, Lupu followed recommendations by Shirley Yates, who is Nutrition House’s franchisee director, and knew the core group of top-selling company products very well. Lupu also conducted on-ground research for the first six months to see what his customers were demanding.

“I would write down what people were looking for if I didn’t have it. I would go to trade shows and conferences and sample and taste test and do my research on the ingredients,” he says. If people requested specific products that his store didn’t carry, he would do his research and then educate and direct them to an alternate product.

As an educator, Lupu wants to let his customers know they can trust his knowledge on the subject. He studies each vendor’s catalogue closely and then does his own research on each ingredient in the products to decide which non-GMO and natural products he would like to keep in his inventory.
As a result, Lupu includes products of choice in every category and places them in a way that makes it clearly visible to everyone who comes to the store.

Keeping Customers Loyal to Your Brand

With the great volume of foot traffic at Yonge and Bloor comes great competition. However, Lupu has never felt threatened by the Shoppers Drugmart across the hall. He feels it’s a matter of duty as a natural health practitioner not to carry mass brands. “It says something if you are selling the same products as Walmart.”

Lupu feels that his store, offers a better selection and loyalty programs such as a Nutrition House loyalty card that gives customers a point for each dollar spent. He also has an in-house discount campaign, exclusive to his location.

“When I first started the store, I started a 10 per cent discount for seniors on an ongoing daily basis under the banner ‘Young at Heart,’ ” he says. A special hand-delivery option is available for loyal, aged customers who are unable to come to the store from their Bloor Street condos. There is also a 10 per cent discount on products for children up to the age of 18, as well as GoodLife members. (Staff at the gym also get 15 per cent off products.)

All holistic practitioners, naturopaths, chiropractics, massage therapists, acupuncturists, homeopaths, personal trainers and natural medicine practitioners also get a 15 per cent discount.

Top Sellers

Lupu strongly recommends that retailers ask their vendors to provide samples. Sampling is crucial in helping patrons decide what they would like to buy. “I work with my vendors to ask them for samples for every order so that customers can try it and commit that they’re going to spend a certain amount of dollars on this product,” he says. This also open doors for furthering the conversation with shoppers.

When it comes to customer favourites, some of his best selling products in the supplements section include, but aren’t limited to, Activ-X Multivitamins for Men and Women by Platinum Naturals; HCP 30 & 70 Probiotics by Progressive; Maca by Preferred Nutrition and Curcumin by Organika.

Among the sports supplements, Lupu finds that the most popular items are True North Nutrition’s Synergenex Ephedrine HCL; Perfect Nutrition’s Burn FX Fat Burner; Natural Factors’ Vegan Greens Protein Bar; Renew Life’s Cerebrum DHA Fish Oil; Naka Professionals’ Naka Pro Collagen Powder and Tristar Naturals’ Tristar Naturals B-100 Complex.

Promotion and Social Media

Lupu’s education as a homeopathic doctor and free in-store guidance is not limited to personal consultancies. He says Instagram and Facebook are a huge help in engaging audiences.

“I tell people to follow us on Instagram to find out what we’re sampling today.”

He often posts educational articles on Facebook so followers can learn something new each time they visit the page. Last September, Lupu started networking on Instagram using an exclusive hashtag #TeamHBC.

He decided to sponsor a few of his employees, who were also amateur bodybuilders at the time. With Lupu’s and Nutrition House’s sponsorship and support John Alexander competed at the Arnold Classic in Ohio earlier this year and at Mr. Olympia held in Las Vegas last year.

Lupu proudly talks about another one of his customers who also took his advice for personal training.
“One of my very first athletes, Fabi Schneider who works at ILAC, competed in and won her very first Ontario Professional Association competition.”

Alexander and Schneider use #TeamHBC to help solidify Lupu’s natural health store as the sports go-to place.
Under the same hashtag, he guides his customers, who are aspiring athletes, about sports nutrition, in particular, and body nutrition in general. In return, they use the exclusive tag in their social media streams, helping drive eye traffic to Lupu’s social media.

In Lupu’s opinion, Instagram and Facebook give him the ability to communicate with his audience in more of a professional manner, as compared to some other social media outlets.

“It’s instant,” he says about Instagram. “I’ll post something and within five minutes I notice I have 50 likes or views, and in my mind, they are potential customers.”

An Educated Staff

“I have been very blessed when it comes to staff,” says Lupu. “One of my [primary] concerns was to hire team members who are educated, motivated, friendly, and as passionate about [the store] as I am.”

His team includes four staff who all have health-related degrees and were past customers, including the enthusiastic Mahwush Ansari. Before joining Lupu’s store, Ansari had already been a part of Nutrition House at another location. (Tramadol 50mg)
“I liked the fact that he’s working so hard to educate people,” says Ansari about her boss. “That’s very important for me when you’re working in the health business.”

Moving Forward

Up next for Lupu is a 12-month marketing campaign with Pattison Ads. “There are almost 50,000 people who walk down this concourse every day and there is opportunity to market ourselves through this.”

Additionally, he and his team will be working on pushing out recurring promotions such as allergy and flu seasons, New Year’s resolution time when people are looking to lose weight, and breast cancer and prostate awareness months.

As a progressive owner, he has partnered with Naka Professionals to create two special bonus packs specific to his location. “We have made an omega-3 house brand with a bottle of 225 capsules matching the price of 175 capsule bottles carried by other retailers.”

Similarly for magnesium bisglycinate, Lupu’s store carries an exclusive bonus size packing of 180 capsules compared to other stores that carry 120 or 150 capsules per bottle.

Lupu would also like to start giving back to the community that has helped him achieve his dream of running a successful business. He wants to request patrons to donate a dollar with every purchase they make at Nutrition House to be donated to SickKids Hospital in Toronto.

His biggest motivation is to maintain the current success levels and to find ways to go even higher by potentially starting a second Nutrition House location within the GTA when the right opportunity comes along.

Collagen: Is there an opportunity?

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Collagen: Is there an opportunity?

A Clinically Proven Ingredient For Healthy Aging

What to look for when stocking your shelves— and information to share with customers

Collagen is a critical protein used to support healthy skin, hair, nails, joints, and bones. Collagen proteins are responsible for regenerating and forming new tissue. This regeneration cycle of collagen fibers slows down as we age, resulting in fewer replacement collagen fibers and a weakened collagen matrix in the body’s tissues. Supplementing with collagen introduces additional collagen peptides into the extracellular fluid. The molecular receptors of the worker cells that produce collagen “turned on” more frequently, thus continuing the regeneration cycle at a healthy rate, and rebuilding the collagen matrix more quickly.

1.5% Per Year AFTER AGE 25
Rate of decline in the regeneration of our skin’s collagen matrix. Regeneration happens quickly during our youth, but declines after the age of 25.

Yes, there is a difference!
Injectable collagen vs. supplemental collagen
You’ve probably heard of injectable collagen, but it’s extremely important to note that collagen supplements are vastly different. In addition to the delivery, injectable collagen is a very large molecule and is used as a filler substance to fill in wrinkles or plump lips. That type of collagen isn’t incorporated into the structure of the body, and is cleared away after a relatively short period of time.
Collagen supplements, on the other hand, are hydrolyzed to a very specific scientifically validated size that when taken orally provide a stimulus to the cells that produce new collagen. Those cells then produce collagen at a faster rate and rebuild the body’s tissues. The new collagen being produced becomes a part of someone and may last months or years.

Types 1&3: Found together in the body, these two types comprise about 90 percent of the body’s collagen, including structures like skin, ligaments, tendons, bones and blood vessels. They are the best choice for beauty benefits (skin, hair and nails) and can also support healthy bones, ligaments and tendons. For joints, they are beneficial for sprained ankles, tendonitis, and knee ligament tears.
Type 2: Found only in cartilage, this type makes up less than 10 percent of the body’s collagen and is best for joint and cartilage support. Common cartilage issues that type 2 collagen can help manage are knee meniscus tears, back disc issues and TMJ jaw popping.

Type 2 collagen should not be taken with types 1&3 because they have different mechanisms of action in the body and can “cancel” each other out. While it is not dangerous to mix all three types, the supplement would have diminished effectiveness. However, taking types 1&3 and type 2 supplements during the same day with several hours in between (such as one in the morning and one at night) is perfectly fine.

What to look for in a supplement
Products should identify the type of collagen on the Supplement Facts panel on the back of the bottle (and they may also call out the types on the front of the label).
Products with the correct dosage: Most published research studies on collagen show that the effective dose is between 2000 mg and 10,000 mg. However, based on certain variables and needs, a person’s ideal collagen intake could vary (such as weight, age, health status, and desired benefit). In general, a higher dose is better and shouldn’t be thought of as harmful. A low dosage only in the hundreds of milligrams will have a minimal effect on the body.
Products that also contain vitamin C: Vitamin C is another important factor in producing collagen and so choosing a product that also contains this nutrient can be beneficial.
The right delivery system: Collagen comes in pills, powders (to add to smoothies or drinks) and chewable forms. It’s most important to help customers find a delivery that encourages them to take the product consistently, which leads to the best results.

Tablet content: NeoCell Clinical Research
In a 2014 study of 26 females between the ages of 30 and 50 years old, taking 6 grams BioActive NeoCell Collagen daily increased skin hydration on an average of 21 per cent after just 12 weeks. Many study subjects experienced more than 30 per cent improvement in skin hydration and some up to 50 per cent.

Highlights from CHFA East 2015

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Highlights from CHFA East 2015

Canada’s largest conference and trade show for the natural health and organics industry, this year’s CHFA East welcomed over 800 exhibitors. Held at the Metro Toronto Convention Center, the 95,000 square-foot show floor was the place to be for the industry’s top manufacturers, distributors and brokers.

Here are some of our product and brand highlights from the show:

– Suro has recently announced plans to sell overseas and CEO Sylvain Mercier was on hand at the CHFA to promote the company’s prominent products, including the Organic Elderberry Syrup especially developed to fight sore throats, colds and coughs.

– Nova Scotia Fisherman unveiled two new lotions – Sea Fennel & Bayberry as well as Seabuckthorn. Both lotions combine new ingredients with the brand’s signature Kelp and are rich in vitamins, minerals, and antioxidants, perfect for healthy skin.

– Purity Life Health Products introduced Kyolic® Curcumin, which combines Curcumin with Aged Garlic Extract to fight inflammation at its source.

– Ascenta had an exciting new launch of the new NutraSea Chocolate Omega-3, one teaspoon of which delivers 1250 mg of EPA + DHA. It’s also great to use in shakes and smoothies!

UNFI cuts cap-ex, names new CFO

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UNFI cuts cap-ex

United Natural Foods, Inc. (UNFI) has announced plans to reduce its capital spending for the next few years.

Steve Spinner, president and CEO of UNFI, explains that the company has completed building out its distribution capacity and thus does not anticipate the need for additional warehouses for close to three years.

Consequently, he says, the Providence-based company plans to reduce capital spending to less than one per cent of revenues over the next several years, with spending between $50 million and $60 million in fiscal 2016 (or 0.6 per cent to 0.7 per cent of sales).

Spinner added that most spending between 2016 and 2018 will be applied to expanding and improving the company’s IT infrastructure, while the cash saved will be used “to facilitate any acquisitions” in the gourmet, ethnic or fresh areas, encompassing proteins, produce, prepared food and specialty cheese.

“Those are the categories where we’re spending most of our energy, and there is a fairly robust pipeline,” he explains. “It’s just a matter of timing.”

UNFI has also revealed the appointment of Michael Zechmeister as its new SVP and CFO. In this position, Zechmeister will succeed Mark Shamber, who will leave at the end of December after 12 years with the company.

Previously, Zechmeister acted as the vice-president of finance for the Yoplait USA division of General Mills, following 25 years in a variety of corporate finance positions with that company.

Organic market booming, notes the OTA

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Organic market booming

On September 17 to 18, the Organic Trade Association (OTA), a membership-based organization of organic food companies, held their All Things Organic Conference in Baltimore. This event provided industry members with critical information on the future of organic goods with a focus on consumer education.

“Despite organic sales and accessibility at all-time highs, consumer confusion about organic benefits remains significant,” says Laura Batcha, CEO of OTA. “Consumers need to know the facts about organic so they can make the smartest choices for themselves and their families.”

Worldwide, organic food sales grew 170 per cent to US$63 billion from 2002 to 2011. Moreover, the OTA notes that in the United States alone, eaters purchased US$35.9 billion of organic food in 2014, representing 4 percent of total food sales in the U.S.
However, much of the consumer base still doesn’t know what the organic label really means. According to a 2014 study published in the International Food and Agribusiness Management Review, 17 percent of American and Canadian consumers think organic food is also locally grown, while another 23 percent believe locally grown food is automatically organic.

This year’s discussions included topics like “Understanding Organic Supply Constraints,” “State of the Organic Industry” and “Organic Market and Consumer Trends.”

For more information about the organic industry, the OTA and other events that are organized or attended by the group, visit www.OTA.com.

Overwaitea converts six stores to Save-On banner

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Overwaitea converts six stores to Save-On banner

Last week, Overwaitea Food Group announced the conversion of some of its existing British Columbia-based Cooper’s Foods and PriceSmart Foods stores to Save-On-Foods locations.

Recently, Save-On-Foods has become one of B.C.’s most popular grocers: in February, the retailer topped the list of the 20 most loved brands in B.C. Additionally, another study from the Peter B. Gustavson School of Business at the University of Victoria found Save-On-Foods to be among the brands Canadians trust most.

To date, six PriceSmart Foods and Cooper’s Foods locations have been re-opened under the Save-On banner. However, despite these conversions, Overwaitea notes that it has no plans to phase out either Cooper’s Foods or PriceSmart.

“We’re always monitoring the markets where we do business to ensure that we provide the customers in each marketplace with the banners they want to see,” says a company spokesperson. “We’re very focused on making sure that we meet the needs of customers—which vary from community to community—and our multi-banner format allows us to do that.”

While Save-On stores currently operate only in B.C. and Alberta, Overwaitea president Darrell Jones made a July announcement regarding an expansion strategy that will see the opening of new Save-On locations in Saskatchewan and Manitoba next year.

Sobeys Quebec now offers certified humane chicken products

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Sobeys Quebec now offers certified humane chicken products

In what is believes to be a first among Canadian retailers, Sobeys Quebec has launched its own brand of humanely certified fresh chicken products as part of its new Compliments Naturally Simple private label. The line includes four ‘Certified Humane’ cuts, including breasts, drumsticks, thighs and flattened chicken.

The new natural Compliments line was launched earlier this summer. Products under this umbrella, which come from animals raised without the use of antibiotics or hormones, are made without the use of artificial sweeteners, colours, flavours or hydrogenated oils.

In addition to those criteria, the Certified Humane certificate ensures that both producers and processors of meat products respect strict standards in terms of breeding, handling, transport, and the slaughter of livestock.

“We feel these new products meet the growing demands of our customers,” says Marie- Noëlle Cano, a spokesperson for Sobeys, “and we’re proud to be the first Canadian retailer to offer them.”

Other Certified Humane brand partners include DuBreton Pork, Aspen Ridge Natural Beef, Blue Goose Poultry and Sunrise Farms, where animals are fed a 100% vegetable grain diet and are raised in low-stress environments.