Duchenne muscular dystrophy (DMD) is a fatal disorder caused by the genetic absence of dystrophin. Oxidative stress and inflammation are directly involved in the progression of the disease. Ten patients with DMD were treated with 60 mg melatonin at 9pm plus 10 mg at 9am daily for 9 months. Plasma levels of 1) inflammatory cytokines interleukin (IL)-1beta, IL-2, IL-6, tumor necrosis factor-alpha, interferon-gamma; 2) markers of oxidative stress: lipid peroxidation (LPO), nitrites (NO(x)); and 3) plasma markers of muscle injury, were measured after 3, 6 and 9 months of treatment. Healthy age- and sex-matched subjects were used as controls. At baseline, DMD patients had elevated levels of LPO, NO(x), and cytokines compared with healthy controls. Melatonin administration reduced these values to control levels at 3 months of treatment, and decreased them further after 9 months. Melatonin also reduced plasma levels of creatine kinase (50%), lactate dehydrogenase (28%), aspartate aminotransferase (28%), alanine aminotransferase (20%), and myoglobin (13%). Melatonin administration reduced the oxidative and inflammatory process in DMD patients, and reduced markers of the muscle degenerative process. (J Pineal Res. 2010 Apr;48(3):282-9.) PMID: 20210854
Enteric-coated peppermint oil for irritable bowel syndrome
Peppermint is a herb with spasmolytic, carminitive properties; the active constituent, menthol, has been shown to relax smooth muscle by blocking Ca2+ channels in the gut. This was a randomized double-blind placebo-controlled study of 90 patients with irritable bowel syndrome (IBS). Subjects took one enteric coated capsule containing 0.2 ml of peppermint oil (Colpermin) or placebo three times daily 30 minutes before each meal for 8 weeks. Patients’ symptoms and quality of life were assessed after the first, fourth, and eighth weeks. The number of patients who were free from abdominal pain or discomfort changed 0 at baseline to 14 (42.5%) at week 8 in the peppermint oil group, compared to from 0 to 6 (22.2%) in the control group (P < 0.001). The severity of abdominal pain was also significantly reduced in the peppermint oil group as compared to controls (p<0.001). Peppermint oil significantly improved patients’ quality of life. There were no significant adverse reactions. The peppermint oil preparation Colpermin is safe and effective in reducing abdominal pain or discomfort in patients with IBS. (Dig Dis Sci. 2010 May;55(5):1385-90.) PMID: 19507027
Exercise pioneer Jack LaLanne dies at 96
The fitness fanatic ate well and exercised — and made it his mission to make sure everyone did the same — right up to the end at age 96, friends and family said. LaLanne died January 23, 2011 at his home in Morro Bay on California’s central coast. The cause was respiratory failure due to pneumonia. LaLanne credited a sudden interest in fitness with transforming his life as a teen, and he worked tirelessly over the next eight decades to transform others’ lives, too. “The only way you can hurt the body is not use it,” LaLanne said. “Inactivity is the killer and, remember, it’s never too late.” He developed exercises that used no special equipment, just a chair and a towel. He also founded a chain of fitness studios that bore his name and in recent years touted the value of raw fruit and vegetables as he helped market a machine called Jack LaLanne’s Power Juicer. In addition to his wife, he is survived by two sons, Dan and Jon, and a daughter, Yvonne.
First PA’s trained at Canadian universities enter workforce
The first civilian physician assistants (PAs) trained in Canada have received their degrees from the University of Manitoba (U of M) and McMaster University. The U of M awarded master of physician assistant studies degrees to its first 10 graduates Oct. 20, 2010. McMaster followed suit Nov. 19 by awarding bachelor of health science (physician assistant) degrees to its first 21 PAs. The University of Toronto will produce its first PA graduates later this year. John Cannington, assistant dean of McMaster’s PA program, said that because of their commitment to collaborative care the new graduates “have positioned themselves as essential members of today’s interprofessional health care teams.” All PAs work under a physician’s supervision. More than 73,000 PAs currently practise in the US, where they have been part of the health care system since the 1960s.
The costs of heart disease in the United States to balloon to over $800 billion a year
Between now and 2030, the costs involved to manage heart disease will triple to more than $800 billion a year, a report commissioned by the American Heart Association predicted. Treating high blood pressure will be the most expensive part of the cost, rising to $389 billion by 2030, the report projects, with overall heart disease rising 10 percent by then. The Heart Association CEO Dr. Nancy Brown said “This country has a choice to make: We can wait until people get sick and figure out how to treat them or we can focus on prevention.” Dr. Paul Heidenreich of the VA Palo Alto Health Care System in California and colleagues looked at current costs of heart disease, the U.S. population and trends in behavior and illness for the first such projection of heart disease costs. “Between 2010 and 2030, real total direct medical costs of cardiovascular disease are projected to triple, from $272.5 billion to $818.1 billion,” reads the report, published in the journal Circulation.
Neptune Revenue up from 2009
Revenue for Neptune Technologies & Bioressources Inc. (NASDAQ.NEPT – TSX.V.NTB) increased for the three-month and nine-month periods ended Nov. 30, 2010, according to consolidated financial results released by the company. Neptune’s nutraceutical revenue also increased during these periods. Consolidated revenue increased by 14% to $4,290,000 for the three-month period ended Nov. 30, 2010, up from $3,758,000 achieved during the corresponding period ended Nov. 30, 2009.
Bioenergy gets US Federal Discovery Grant
Bioenergy Inc. has received notification of a federal grant in the amount of $244,000 as part of the Qualifying Therapeutic Discovery Project. The company said it will use the grant funds to investigate their patented D-Ribose’s role in protecting the heart and improving heart function. The Qualifying Therapeutic Discovery Project Credit (QTDP) is provided under section 48D of the Internal Revenue Code (IRC), as added to the IRC by the Patient Protection and Affordable Care Act of 2010 (P.L. 111-148). The project issues one-time awards to biotech companies that show significant potential to produce new therapies; address unmet medical needs; prevent, detect, or treat chronic or acute diseases or conditions; reduce health care costs, or significantly advance the goal of curing cancer within the next 30 years. “This is exciting news for our company as we continue to work with D-Ribose and its application for cardiovascular health,” said Raj Khankari, CEO of Bioenergy, Inc. “We are very grateful the federal government has recognized the value of our company’s work and will be supporting us in our efforts as we continue to move forward.
Mixing common antibiotics with BP medication in older patients may result in hospitalization
From the Canadian Medical Association Journal (CMAJ) media release: Mixing commonly used antibiotics with common blood pressure medications may cause hypotension and induce shock in older patients, requiring hospitalization, according to a study published in CMAJ (Canadian Medical Association Journal). “Macrolide antibiotics (erythromycin, clarithromycin and azithromycin) are among the most widely prescribed antibiotics, with millions of prescriptions dispensed in Canada each year” writes Dr. David Juurlink, Scientist at the Sunnybrook Research Institute and the Institute for Clinical Evaluative Sciences with coauthors. “The drugs are generally well-tolerated, but they can cause several important drug interactions.” This study was conducted among Ontarians 66 years and older who were treated with a calciumchannel blocker between 1994 and 2009. The researchers identified 7100 patients hospitalized for low blood pressure or shock while taking a calcium channel blocker. Treatment with erythromycin was found to increase the risk of low blood pressure almost 6-fold, while clarithromycin increased the risk almost 4-fold. In contrast, azithromycin did not increase the risk of hypotension.
Medical device manufacturer pleads guilty & sentenced to pay more than $296 million in fines
Guidant LLC was formally convicted and ordered to pay more than $296 million in criminal fines and 3 years probation for withholding information about its heart defibrillators. The government said Guidant made decisions at various junctures to conceal information from the FDA and medical professionals regarding the device failures. In June 2005, the company finally “went public about the problem with information it had known for 10 months, and then only after three deaths had occurred,” according to a Justice Department statement. The Boston Scientific Corporation – which acquired Guidant LLC after the misconduct occurred – admitted to criminal violations relating to its interactions with the U.S. Food and Drug Administration last April. The U.S. Justice Department brought the charges against Guidant for its mishandling of short-circuiting failures of three models of its implantable cardioverter defibrillators: the Ventak Prizm 2 DR (Model 1861) and the Contak Renewal (Models H135 and H155).
Medical Practices allowing online appointments
There exists a growing number of medical practices that allow patients to schedule appointments online. About 16% of family doctors used online scheduling in 2009, up from 6% in 2005, according to the American Academy of Family Physicians. Several factors are driving the trend. On the doctors’ side, it’s mostly the need to add patients and reduce overhead costs. They’re also growing more comfortable with computers. About half of family doctors use electronic health records, and 44% prescribe electronically, according to the academy. CEO Cyrus Massoumi says he envisions ZocDoc doing for doctor and dentist appointments what opentable. com has done for restaurant reservations. About 40% of ZocDoc appointments take place within a day of booking. After an appointment is made online, the doctor’s office confirms it by e-mail, then ZocDoc sends electronic reminders. Nearly 85% of appointments made on ZocDoc are new patients. Patients pay nothing. Doctors pay about $250 a month to be listed.












