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Coenzyme Q10 supplementation in early chronic Peyronie’s disease

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A total of 186 patients with chronic early Peyronie’s disease (PD) were assigned to either 300 mg CoQ10 daily or placebo for 24 weeks. Erectile function (EF), pain during erection, plaque volume, penile curvature and treatment satisfaction using patient versions of the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire were assessed at baseline and every 4 weeks during study period. EF was assessed using International Index of Erectile Function (IIEF-5), and pain was evaluated with a visual analog scale (VAS, 0-10). After 24 weeks, mean IIEF-5 score, mean VAS score and mean EDITS score improved significantly in patients receiving CoQ10 (all P<0.01). Mean plaque size and mean penile curvature degree were decreased in the CoQ10 group, whereas a slight increase was noted in the placebo group, resulting in a significant difference between groups (both P=0.001). Mean index of IIEF-5 in 24-week treatment period was 17.8 ± 2.7 in the CoQ10 group and 8.8 ± 1.5 in the placebo group (P=0.001). Of the patients in CoQ10 group, 11 (13.6%) had disease progression compared to 46 (56.1%) in placebo group (P=0.01). Int J Impot Res. 2010 Sep-Oct;22(5):298-309. PMID: 20720560.

(Phentermine)

Effect of Alpha-lipoic Acid on body weight in obese subjects.

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Alpha-lipoic acid (ALA) is an essential cofactor for mitochondrial respiratory enzymes and improves mitochondrial function. ALA has previously been reported to reduce body weight gain in rodents. This study examined whether alpha-lipoic acid reduces body weight in obese human subjects. In a randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (BMI ≥30 or BMI 27-30 plus hypertension, diabetes mellitus, or hypercholesterolemia) received either ALA 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline. After 20 weeks, subjects in the 1800mg ALA group lost significantly more weight than the placebo group (2.1%, 95%CI 1.4-2.8; p<.05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient. Alpha-lipoic acid leads to modest weight loss in obese subjects, and may be considered as adjunctive therapy for obesity. Am J Med. 2011 Jan;124(1):85.e1-8. PMID: 21187189.

The role of garlic in hepatopulmonary syndrome: a randomized controlled trial.

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A total of 41 hepatopulmonary syndrome (HPS) patients were randomly assigned to receive either oral garlic supplementation (dose not available) or placebo, and were evaluated monthly over a period of nine to 18 months. After nine months, garlic supplementation was associated with a 24.66% increase in baseline arterial oxygen levels (83.05 mmHg versus 66.62 mmHg; p<0.001), compared with only a 7.37% increase (68.75 mmHg versus 64.05 mmHg; p=0.02) among subjects in the placebo group. There was also a 28.35% decrease in alveolar-arterial oxygen gradient (21.35 mmHg versus 29.77 mmHg; p<0.001) among patients with HPS who received garlic, in contrast with only a 10.73% decrease (29.11 mmHg versus 32.61 mmHg; p=0.12) among those in the placebo group. After nine months, the arterial oxygen level was significantly higher (83.05 mmHg versus 68.75 mmHg; p<0.001) and the alveolar-arterial oxygen gradient was significantly lower (21.35 mmHg versus 29.11 mmHg; p<0.001) among patients receiving garlic compared with those receiving placebo. Reversal of HPS was observed in 14 of 21 patients (66.67%) on garlic supplementation and in one of 20 patients (5%) on placebo. Two of 21 patients undergoing garlic supplementation died during follow-up in contrast to seven of 20 patients who were on placebo. Can J Gastroenterol. 2010 Mar;24(3):183-8. PMID: 20352147.

L-theanine in patients with schizophrenia and schizoaffective disorder

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A total of 60 patients with DSM-IV schizophrenia or schizoaffective disorder participated in an 8-week, double-blind, randomized, placebo-controlled study: 400 mg/d of L-theanine was added to ongoing antipsychotic treatment from Feb 2006 until Oct 2008. Outcome measures were the Positive and Negative Syndrome Scale (PANSS), the Hamilton Anxiety Rating Scale (HARS), the Cambridge Neuropsychological Test Automated Battery (CANTAB) for neurocognitive functioning, and additional measures of general functioning, side effects, and quality of life. 40 of the 60 patients completed the study protocol. Compared to placebo, L-theanine augmentation was associated with reduction of anxiety (P = .015; measured by the HARS scale) and positive (P = .009) and general psychopathology (P < .001) scores (measured by the PANSS 3-dimensional model). According to the 5-dimension model of psychopathology, L-theanine produced significant reductions on PANSS positive (P = .004) and activation factor (P = .006) scores compared to placebo. PANSS negative and CANTAB task scores, general functioning, side effect, and quality of life measures were not affected. L-theanine augmentation of antipsychotic therapy can ameliorate positive, activation, and anxiety symptoms in schizophrenia and schizoaffective disorder patients. J Clin Psychiatry. 2011 Jan;72(1):34-42. PMID: 21208586.

Weight training is safe for pregnant women

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Adopting a supervised, low-to-moderate intensity weight-lifting exercise program can be safe for women with a low-risk pregnancy, according to a University of Georgia media release. Despite decades of doctors’ reluctance to recommend weight training to pregnant women, a new University of Georgia study has found that a supervised, low-to-moderate intensity program is safe and beneficial. The research, published in the current edition of the Journal of Physical Activity and Health, measured progression in the amount of weight used, changes in resting blood pressure and potential adverse side effects in 32 pregnant women over a 12-week period. The group increased the amount of weight lifted in all of the exercises by an average of 36 percent over the 12-week period. After a total of 618 exercise sessions, none of the pregnant women in the study experienced a musculoskeletal injury. Thirteen incidents of potentially problematic symptoms were reported, all of which involved headache, pelvic pain and dizziness. Some pelvic pain can be expected in pregnant women with back pain, said researcher Patrick O’Connor. “The one thing you have to be a little careful about is dizziness,” he added. Rates of dizziness went down after the first few workouts, as the women learned to lift weights while maintaining proper breathing techniques for exercise, he said. One reason physicians have been reluctant to prescribe weight lifting to pregnant women is that they produce high amounts of a hormone called relaxin, which promotes connective tissue laxity, explained O’Connor. Increased laxity could be associated with orthopedic injury. O’Connor stated “I think that the appropriate conclusion of this study is that the adoption of a supervised, low-to-moderate intensity weight-lifting exercise program can be safe for women with a low-risk pregnancy.”

Interprofessional Dialogue at National Health Sciences Students’ Conference

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Canadian College of Naturopathic Medicine student Marnie LaPlante presented her research and led an interactive workshop on ‘Integration and patient centered medicine – its meaning and implications for a collaborative medicine’ at the National Health Sciences Students’ Association (NaHSSA) Conference recently. The theme of this year’s conference was Crossing the Bridges of Socioeconomic and Cultural Diversity in Healthcare and is an ongoing interprofessional collaborative initiative involving students, faculty and practitioners from University of Toronto and University of Ottawa medical schools, The Canadian Memorial Chiropractic College, and CCNM. Additional research from CCNM was on display from the work done investigating naturopathic medicine and Aboriginal health care delivery including qualitative research done on the satellite clinic at Anishnawbe Health Toronto.

Organic Consumers Association: The Organic Elite Surrenders to Monsanto

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The Organic Consumers Association (OCA) recently reported on a controversial battle in the organic food industry to keep Monsanto’s Genetically Engineered (GE) crops from contaminating the nation’s 25,000 organic farms and ranches. The OCA states that “A self-appointed cabal of the Organic Elite, spearheaded by Whole Foods Market, Organic Valley, and Stonyfield Farm, has decided it’s time to surrender to Monsanto.” Top executives from these companies have publicly admitted that they no longer oppose the mass commercialization of GE crops, such as Monsanto’s controversial Roundup Ready alfalfa, and are prepared to sit down and cut a deal for “coexistence” with Monsanto and USDA biotech leader Tom Vilsack. Organic farmers remain concerned that the massive planting of a GE perennial crop, alfalfa, will result in the spread of its GE genes and seeds, contaminating the alfalfa fed to organic animalsandpotentiallycrossingtonon-GE species through cross pollination.

Focus on integrative mental health for conventional academic consortium

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TheConsortiumofAcademicHealthCenters for Integrative Medicine (CAHCIM) has chosen to highlight developments in integrative mental health. According to a recent notice to members, the CAHCIM executive committee approved establishment of a sub-group of the CAHCIM Clinical Working Group that focuses on integrative mental health care. The action was taken “in response to the unsatisfactory state of mental health care in the U.S. and other countries, and increasing public and research interest in integrative mental health care.” The new sub-group operates with 4 goals:
• systematically evaluating research evidence pertaining to non-conventional and integrative assessment and treatment approaches in mental health care
• recommending research priorities to the Consortium leadership
• developing resources for educating and training mental health professionals in integrative mental health care, and
• establishing best practice clinical guidelines in integrative mental health care for common psychiatric disorders. Important aspects of the group’s work in 2011 are expected to be developing an agenda on research priorities in integrative mental health and facilitating collaborative research efforts between different Consortium member institutions. Leaders include Ron Glick, MD and Kelsey Hippen.

Growing Use Of Alternative Medicine In Pregnancy Highlights Need For More Knowledge

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A recent study out of Queensland University in Australia reports that complementary and alternative medicine (CAM) has become increasingly popular in maternity care. Healthcareprofessionalsneedmoreevidence- based information about its use, according to Dr Adams, lead author and Executive Director of the Network of Researchers in the Public Health of Complementary and Alternative Medicine (NORPHCAM). Adams says there is a need for greater respect and cooperation between conventional and alternative practitioners. The study reviewed 19 studies covering the views of more than 3,000 maternity professionals from Australia, Canada, the USA, UK, Germany, New Zealand and Israel. The review raised concern that most medical professionals have no CAM training and little understanding of the pharmacological nature of alternative therapies and their possible risks to pregnant women. The study was published in the most recent issue of the Journal of Advanced Nursing. Key findings from the most recent 2008 and 2009 studies include: * A survey of 343 midwives from Canada and New Zealand found that 72 per cent had recommended or offered CAM. The most common referrals were to homeopaths (51 per cent), acupuncturists (50 per cent), naturopathic doctors (48 per cent), chiropractors (36 per cent), massage therapists (31 per cent) and osteopaths (20 per cent).
8 A study of 401 American obstetricians found that 98 per cent routinely endorsed, provided or referred patients for at least one CAM treatment. Movement therapies topped the list at 86 per cent, followed by biofeedback and acupuncture (both 80%).
* All but one of the 381 obstetric departments who took part in a German survey said they offered at least one CAM therapy, with acupuncture (97 per cent), homeopathy (93 per cent) and aromatherapy (77 per cent) heading the list.

MD Anderson Center Receives Grant For Study Of Acupuncture In Cancer

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The University of Texas MD Anderson Cancer Center has been awarded a grant to study whether xerostomia, a debilitating side effect caused by head and neck cancer radiation treatment, can be prevented when acupuncture is part of a patient’s treatment regimen. The $2.7 million grant from the National Cancer Institute (NCI) for the study of acupuncture in cancer was awarded to Lorenzo Cohen, Ph.D., professor in the Departments of General Oncology and Behavioral Science. The MD Anderson has offered acupuncture, when appropriate, to patients for pain or other cancer or treatment-related symptoms since 2004. This Phase III randomized clinical trial will enroll 300 head and neck cancer patients receiving radiation treatment at either Shanghai Cancer Center or MD Anderson. Those enrolled in the sister Shanghai center will have nasopharyngeal carcinoma, a malignancy much less common in the United States. Prior to undergoing radiation, patients will be randomized to receive either acupuncture (needles inserted at appropriate, selected points), sham acupuncture (real and placebo needles inserted at inactive points), or standard care. Subjective and objective assessments of xerostomia will be collected prior to, during and at the completion of therapy, as well at three, six and 12 months post-radiation.