An international research team led by two laboratories from Weill Cornell Medical College have developed a new experimental drug to target an aggressive form of lymphoma, called activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL). An experimental small molecule agent called MI-2 irreversibly inactivates a key protein, MALT1, that is responsible for driving the growth and survival of lymphoma cells. In their study, the researchers showed that the MI-2 inactivates any MALT1 it comes into contact with and also does so without any apparent toxicity in animal models.
